Migraine with aura pregnancy11/12/2023 For more information, please see the bump leaflets on Gabapentin, Venlafaxine, and Botulinum toxin. They are not known to harm the developing baby but more information on their pregnancy safety is ideally required. Gabapentin, venlafaxine, and botulinum toxin are only used in pregnancy to prevent migraine if other medicines have not worked or cannot be used. For more information, please see the bump leaflet on Topiramate. Topiramate is also avoided in pregnancy as it is linked to a slightly increased risk of cleft lip and palate in the baby and might also affect the baby’s growth in the womb. For more information, please see the bump leaflets on Sodium valproate and ACE inhibitors. Women taking these medicines to prevent migraine should urgently arrange to see their doctor, who will offer a safer alternative. Sodium valproate and a family of medicines called ACE inhibitors (including captopril, cilazapril, enalapril, fosinopril, imidapril, lisinopril, moexipril, perindopril, quinapril, ramipril, and trandolapril) should not be used in pregnancy as they can harm the baby. Sometimes the medicine that was being taken before pregnancy to prevent migraine may need to be changed to an alternative that is safer for the baby. Migraine does not always improve in pregnancy and some women may need to keep taking preventative treatment to ensure that they can function well. ![]() This is because there is very little pregnancy safety information about buclizine. The over-the-counter medicine Migraleve (which contains paracetamol, codeine, and the anti-sickness medicine buclizine) should only be used in pregnancy on advice from a doctor. For more information, please see the bump leaflets on Cyclizine, Prochlorperazine, and Metoclopramide. These drugs are also used to treat pregnancy sickness and are not known to be harmful to a developing baby. For more information, please see the bump leaflet on Codeine.Ĭyclizine, prochlorperazine, or metoclopramide may be offered for nausea and vomiting caused by migraine. Codeine use in the weeks leading up to delivery can cause withdrawal symptoms in the baby after birth. While the majority of exposed babies show no long-term effects, some studies have shown that certain birth defects are slightly more common after codeine use in early pregnancy. For more information please see the bump leaflet on Sumatriptan.Ĭodeine may be offered if other treatments have not worked. There is no evidence that use of sumatriptan in pregnancy is harmful to the baby. Sumatriptan may be offered if paracetamol has not controlled the pain and an NSAID cannot be used. We will be updating this document as soon as possible to include the new advice. For more information, please see the information here. The advice to avoid any use of NSAIDs after 30 weeks of pregnancy has not changed. It is now recommended that prolonged use of NSAIDs should be avoided after 20 weeks of pregnancy. PLEASE BE AWARE: The advice about use of NSAIDs in pregnancy has recently changed. For more information please see the bump leaflets on Ibuprofen, Diclofenac, and Naproxen. It is very important that NSAIDs are not used after 30 weeks of pregnancy as, at this stage, they may affect the baby. Non-steroidal anti-inflammatory drugs (NSAIDs) might be recommended by a doctor in the first and second trimesters if paracetamol does not control migraine pain. For more information please see the bump leaflet on Paracetamol. It has an excellent overall safety profile. Paracetamol is the first-choice treatment for mild-to-moderate pain in pregnancy. Medicines to treat migraine should only be used in pregnancy on the advice of a doctor, who will help to weigh up the benefits of treatment against any risks. ![]() If drug treatment in pregnancy is required, there are a number of options to ensure that migraine does not affect quality of life and interfere with daily activities. However, this does not work for everyone.
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